Hydrazine → HCID 13251444, compound

HRID 542444Notes

Reaction equation

HRID 542444 reaction equation
[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:18][CH:19]([C:23](=O)[CH3:24])[C:20](=O)[CH3:21])[CH2:3]1.[NH2:26][NH2:27]>CO>[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:18][C:19]2[C:23]([CH3:24])=[N:26][NH:27][C:20]=2[CH3:21])[CH2:3]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 70431850HCID 70431850, compound

Product 1

HCID 13251444HCID 13251444, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3 g of 6-methyl-8β-(3-oxo-2-acetyl-butyl)-ergoline, prepared as described in U.S. Pat. No. 4,252,941, 100 ml of methanol and 3 ml of hydrazine was refluxed for 1 hour. After evaporation to dryness in vacuo the residue was crystallized from methanol to give 2.5 g of the title compound, m.p. >300° C.

Workup

  1. customprepared
  2. customAfter evaporation to dryness in vacuo the residue
  3. customwas crystallized from methanol

Sources & evidence

ORD record
ord-19521580e6f84ee6ba21b133cf60e45c
Source dataset
uspto-grants-1987_04
Patent number
US04657914

Reaction notes

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