反应详情

温度

0 °C

To one liter of concentrated sulfuric acid was added, at 5° C., 100 ml of 1,2,3,4-tetrafluorobenzene. Then a mixture of 100 ml of 70% nitric acid premixed with 200 ml of concentrated sulfuric acid at 0° C. was slowly added. The reaction was stirred at 0° C. for one hour, and then one hour at 25° C. The mixture was poured over ice and extracted with dichloromethane, which was dried and concentrated to give 120 g of a thick residue which was one spot thin layer chromatography. This product was used for the next step without purification.

1. additionwas slowly added
2. customone hour
3. customat 25° C
4. additionThe mixture was poured over ice
5. extractionextracted with dichloromethane, which
6. customwas dried
7. concentrationconcentrated