HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Amino-2-(4-phthalimidobut-2-ynylthio)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-(4-chlorobut-2-yn-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione | HCID 237537 | — |
| Reactant | 1,5-Diazabicyclo(5,4,0)undec-5-ene | HCID 314112 | — |
| Reactant | HCID 178507915 | HCID 178507915 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Amino-2-(4-phthalimidobut-2-ynylthio)pyrimidine | HCID 20208713 | 94.1% |
Reaction Steps
A mixture of thiocytosine (0.5 g.), N-(4-chlorobut-2-ynyl)phthalimide (1.03 g.), DMF (5 ml.) and 1,5-diazabicyclo[5,4,0]undec-5-ene (0.67 g.) was stirred for 2 hours. The solution was treated with water (20 ml.) and EtOAc (10 ml.) and the insoluble solid collected to give 4-amino-2-(4-phthalimidobut-2-ynylthio)pyrimidine (1.2 g.) m.p. 197°-202° (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04657908 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-647ff6b73fba46299c6db92f0c4f14a2 |
| Source note | uspto-grants-1987_04 |