Sec-Butylamine → HCID 17278316, compound

Participants

Reaction Steps

250 mg of 2-carbomethoxyphenylisocyanate (Compound II), prepared as described in Preparation I above, and 0.145 ml of sec-butylamine in dry tetrahydrofuran were stirred at room temperature for about 8 hours. The solvent was removed under reduced pressure and the resulting solid was recrystallized from ether and petroleum ether to give methyl 2-(3-sec-butylureido)-benzoate, m.p. 124°-124° C.; 'H NMR:(delta CDCl3); 0.95 (s, 3H, CH3CH2), 1,2(d, 3H, CH3CH), 1,5(m, 2H, CH3CH2), 3.8 (m, 1H, CH--N), 3.9 (s, 3H, OCH3), 4.6 (broad s, 1H, CONH--sec--Bu), 6.8, 7.2 (2 m, 2H, Ar--H), 8.0, 8.6 (2 dd, 2H, Ar--H), 10.3 (broad, 1H, ArNHCO).

Provenance & Evidence