HRID542503

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]

HCID2724136

[2-(Dimethylamino)ethyl](triphenyl)phosphanium bromide

C22H25BrNP

结构：Cc1ccc(C(=O)c2cccc(/C=C/C(=O)O)n2)cc1

HCID11971260

2-Propenoic acid, 3-[6-(4-methylbenzoyl)-2-pyridinyl]-, (E)-

C16H13NO3

PRODUCTS

生成物

$结构：Cc1ccc(/C(=C\CN(C)C)c2cccc(/C=C/C(=O)O)n2)cc1$

HCID13191753

未命名化合物

PROCEDURE

实验过程

Treatment of (E)-3-[6-(4-toluoyl)-2-pyridyl]acrylic acid, vide supra, with the Wittig reagent derived from triphenyldimethylaminoethylphosphonium bromide by the method of example 1 gave a mixture of isomeric acids which were separated by fractional crystallization from ethyl acetate. The less-soluble E-isomer, (E)-3-{6-[3-dimethylamino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid was puried by crystallization from isopropanol, m.p. 222°-225° (decomp.)

WORKUP

后处理

customgave
additiona mixture of isomeric acids which
customwere separated by fractional crystallization from ethyl acetate
customThe less-soluble E-isomer, (E)-3-{6-[3-dimethylamino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid was puried by crystallization from isopropanol, m.p. 222°-225° (decomp.)