Methyl acetoacetate → HCID 54076783, compound

HRID 542525Notes

Reaction equation

HRID 542525 reaction equation
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH:9](OC)(OC)[O:10][CH3:11].C(OC(=O)C)(=O)C>>[CH3:9][O:10][CH:11]=[CH:5][C:3](=[O:4])[CH2:2][C:1]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 3

HCID 7757Methyl acetoacetateHCID 7918Acetic AnhydrideHCID 9005Trimethyl orthoformate

Product 1

HCID 54076783HCID 54076783, compound

Procedure

From methyl acetoacetate (30.2 g, 0.26 mol), trimethyl orthoformate (26.7 g, 0.18 mol) and acetic anhydride (53 g., 0.52 mol): 4.3 g, 15%; bp=100°-105° C. at 0.5 mm Hg (lit.1 80°-84° C. at 0.15 mm Hg); NMR (CDCl3) δ 2.4 (d, 3H), 3.8 (d, 3H), 4.1 (s, 3H), 7.6 (d, 1H).

Workup

  1. customat 0.5 mm Hg (lit.1 80°-84° C. at 0.15 mm Hg)

Sources & evidence

ORD record
ord-4c03ab1ee6294654905771329ee29d4d
Source dataset
uspto-grants-1987_04
Patent number
US04657919

Reaction notes

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