Acetic Anhydride → Isopropyl ethoxymethyleneacetoacetate

Participants

Reaction Steps

From isopropyl acetoacetate (28.8 g, 0.20 mol) which can be made by the process described by Lawesson etal., Organic Synthesis, Coll. Vol. V, 155-157 (1973), triethyl orthoformate (29.6 g, 0.20 mol) and acetic anhydride (41 g, 0.40 mol): 14.3 g, 35.7%; bp=85°-90° C. at 0.20 mm Hg; NMR (CDCl3) δ 1.3-1.6 (m, 9H), 2.3-2.6 (d, 3H), 4.1-4.5 (m, 2H), 5.0-5.4 (m, 1H), 7.6-7.8 (d, 1H).

Provenance & Evidence