HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 5-Acetyl-2-hydroxy-6-methylnicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | 2-Pyridone | HCID 8871 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 53800728 | HCID 53800728 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Acetyl-2-hydroxy-6-methylnicotinonitrile | HCID 2765476 | 28% |
Reaction Steps
From cyanoacetamide (0.02 mol), sodium metal (0.02 g-atom) in MeOH (10 ml), and 5 (0.02 mol): 1.0 g, 28% yield; mp=233°-4° C.; NMR (DMSO-d6) δ 2.5 (s, 3H), 2.6 (s, 3H), 8.8 (s, 1H); IR (KBr), 1660 cm-1 (C=O of pyridone), 1690 cm-1 (C=O of ketone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04657919 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-1cef8c10c8fa4f88a365948797e3a573 |
| Source note | uspto-grants-1987_04 |