HCID 178498220, compound → HCID 178464171, compound

HRID 542532Notes

Reaction equation

HRID 542532 reaction equation
C(C1C(O)=C[C:14](O)=[C:13]2C=1[N:5]=[C:6]1[C:11](=[N:12]2)C(C(OC)=O)=CC=C1O)=O.[CH:24]([C:26]1[C:39]([OH:40])=[C:38]([CH3:41])[C:37]([OH:42])=[C:36]2[C:27]=1[N:28]=[C:29]1[C:34](=[N:35]2)[C:33]([C:43](OC)=[O:44])=[CH:32][CH:31]=[C:30]1[OH:47])=[O:25].[CH3:48]OC(C1C=CC(O)=C2NC3C(=NC=12)C(=O)C=C(O)C=3C=O)=O>>[CH2:13]([N:12]([CH3:48])[CH2:11][CH2:6][NH:5][C:43]([C:33]1[C:34]2[C:29](=[N:28][C:27]3[C:36]([N:35]=2)=[C:37]([OH:42])[C:38]([CH3:41])=[C:39]([OH:40])[C:26]=3[CH:24]=[O:25])[C:30]([OH:47])=[CH:31][CH:32]=1)=[O:44])[CH3:14]

Participants

4

Reactant 3

HCID 178498220HCID 178498220, compoundHCID 178498221HCID 178498221, compound3×HCID 178498230HCID 178498230, compound

Product 1

HCID 178464171HCID 178464171, compound

Procedure

Compounds in accordance with the present invention are prepared from the starting materials 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester or from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester. The former compound, 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester, is known variously in the chemical literature as lomofungin or lomondomycin and is produced in isoluble quantities from fermentation broth mixtures containing the microorganism Streptomyces lomondensis NRRL 3252 as detailed in U.S. Pat. No. 3,359,165.

Workup

  1. customis produced in isoluble quantities from fermentation broth mixtures
  2. additioncontaining the microorganism Streptomyces

Sources & evidence

ORD record
ord-8eee714e82df468ea991aef5a95553d1
Source dataset
uspto-grants-1987_04
Patent number
US04657909

Reaction notes

Loading…