2,2-Dimethoxypropane → HCID 13672387, compound

Participants

Reaction Steps

In this example, 5 m moles of 4-benzyloxy-2-(10-formyldecyl) quinoline-N-oxide is dissolved in dichloromethane, and a catalytic amount of D-camphorsulfonic acid and a large excess of 2,2-dimethoxypropane are added thereto. The mixture is stirred at room temperature for 3 hours. After the reaction, the reaction solution is washed with an aqueous saturated sodium hydrogen carbonate solution, and then with water, and dried over anhydrous sodium sulfate. After removal of the solvent by distillation, the residue is purified by silica gel column procedure, whereby the captioned compound is obtained as a colorless oily substance (yield: 70.6%).

Provenance & Evidence