Indomethacin → HCID 70430505, compound

Participants

Reaction Steps

10 g of indometacin, 4 g of potassium carbonate, 0.3 g of benzyltriethylammonium chloride and 50 ml of acetone are stirred for 30 minutes at 50°-60° C. After addition of 6.32 g of cinnamyl chloroacetate stirring is continued for 3 to 4 hours at 40° C. (check by thin layer chromatography). After filtration, and distilling off the solvent, the residue is recrystallized first from ether/petroleum ether and then from acetone/water.

Provenance & Evidence