HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → 5-(Trifluoromethyl)oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | Ethyl (methylthio)acetate | HCID 78199 | — |
| Reactant | Tert-Butyl hypochlorite | HCID 521297 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 5-(Trifluoromethyl)oxindole | HCID 3734457 | — |
Reaction Steps
In analogous fashion, 4-trifluoromethylaniline was reacted with t-butyl hypochlorite, ethyl 2-(methylthio)acetate and triethylamine followed by reduction of the 3-thiomethyl-5-trifluoromethyl-2-oxindole thus obtained with Raney nickel, to give 5-trifluoromethyl-2-oxindole, mp 189.5°-190.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04658037 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-b4130aa8246642d19f89105f39d469c2 |
| Source note | uspto-grants-1987_04 |