Lithium Chloride → 6-bromo-2,3-dihydro-1H-indol-2-one

HRID 542607Notes

Reaction equation

HRID 542607 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C(OC)=O)[C:9](OC)=[O:10])=[C:4]([N+:17]([O-])=O)[CH:3]=1.[Cl-].[Li+]>CS(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([CH2:8][C:9](=[O:10])[NH:17]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 433294Lithium ChlorideHCID 157405961,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate

Product 1

HCID 27732896-bromo-2,3-dihydro-1H-indol-2-one

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of 17.4 g of dimethyl 2-(4-bromo-2-nitrophenyl)malonate and 4.6 g of lithium chloride in 150 ml of dimethyl sulfoxide was placed in an oil bath at 100° C. After 3 hours, the reaction mixture was

Sources & evidence

ORD record
ord-6ec6e904fc004a609a02eae673e3bfc1
Source dataset
uspto-grants-1987_04
Patent number
US04658037

Reaction notes

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