5-Nitro-2-oxindole → HCID 22042152, compound

HRID 542609Notes

Reaction equation

HRID 542609 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)NC(=O)[CH2:5]2.[N+:12]([C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19](=[O:24])[CH2:18]2)([O-])=O.NC1C=C2C(=CC=1)NC(=[O:35])C2>>[C:5]([NH:12][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19](=[O:24])[CH2:18]2)(=[O:35])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:2][CH:3]=1

Participants

4

Reactant 3

HCID 2303665-Nitro-2-oxindoleHCID 6111935-Bromo-2-oxindoleHCID 27732135-Amino-2-oxindole2×

Product 1

HCID 22042152HCID 22042152, compound

Procedure

5-Bromo-2-oxindole, 5-nitro-2-oxindole and 5-amino-2-oxindole can be prepared as described in Beckett et al., Tetrahedron, 24, 6093 (1968). 5-Amino-2-oxindole can be acylated to give 5-alkanamido-2-oxindole and 5-benzamido-2-oxindole, using standard procedures.

Sources & evidence

ORD record
ord-ac7b8c60b8f54b0da371fda32b0df4f0
Source dataset
uspto-grants-1987_04
Patent number
US04658037

Reaction notes

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