Hydrochloric Acid → HCID 10399143, compound

Participants

Reaction Steps

A mixture of N2 -benzyloxycarbonyl-N-(3-methylbutyl)-L-phenylalaninamide (7.0 g.), ethanol (200 ml.) and palladium on carbon (10%, 250 mg.) was hydrogenated under pressure (40 p.s.i.g.) for three hours (10% uptake). Concentrated hydrochloric acid (1.65 ml.) was added and the hydrogenation was continued overnight. The mixture was filtered, and the filtrate was stripped of volatiles. A small amount of crystals separated from an ether-ethanol solution of the residue. The mother liquor was stripped of volatiles and purified by reverse phase high pressure liquid chromatography on octadecylsilated silica gel using ammonium acetate (0.2%) in methanol-water (65:35) as the eluant, affording N-(3-methylbutyl)-L-phenylalaninamide (2.5 g.) as a clear gum.

Provenance & Evidence