HCID 13669982, compound → HCID 13669983, compound

HRID 542652Notes

Reaction equation

HRID 542652 reaction equation
[N+:1]([C:4]1[C:9]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:16])([O-])=O>[Pd].[C].C(O)C>[CH3:16][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[C:4]=1[NH2:1]

Participants

4

Reactant 1

HCID 13669982HCID 13669982, compound

Product 1

HCID 13669983HCID 13669983, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To 60 ml of an ethanol solution containing 10 g (42.6 mmol) of 2-nitro-3-(2,2,2-trifluoroethoxy)toluene, 1 g of 5 wt% Pd-carbon catalyst, and catalytic reduction was performed at atmospheric pressure and room temperature. After performing thin-layer chromatography to confirm that all the starting material had been consumed, the catalyst was filtered off and the filtrate was concentrated to provide 8.7 g of 2-methyl-6-(2,2,2-trifluoroethoxy)aniline as an oil.

Workup

  1. customwas performed at atmospheric pressure and room temperature
  2. customhad been consumed
  3. filtrationthe catalyst was filtered off
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-b91566d12e69454482af8fe80904c839
Source dataset
uspto-grants-1987_04
Patent number
US04659365

Reaction notes

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