Ethyl 2,4,6-trimethylpyrimidine-5-carboxylate → HCID 13934576, compound

Participants

Reaction Steps

(a) Ethyl 2,4,6-trimethylpyrimidine-5-carboxylate [11.0 g; prepared according to Urban & Shnider, Helv. Chim Acta, 41, 1806 (1958)] was stirred with a slight excess of lithium aluminium hydride in dry tetrahydrofuran (100 ml) at room temperature for 2 hr. The solvent was evaporated and the residue was shaken with a little water. The dried (MgSO4) ethyl acetate extract was evaporated and the residue was purified by column chromotography over alumina with ethyl acetate elution to give 5-(hydroxymethyl)-2,4,6-trimethylpyrimidine as white crystals, mp 68° C.

Provenance & Evidence