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4-Nitrophenol → HCID 178476832、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 反応物 | Diethyl p-aminobenzylphosphonate | HCID 88358 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | HCID 178476832 | HCID 178476832 | — |
反応手順
Diethyl p-aminobenzylphosphonate (1) (Aldrich Chemical Co., Milwaukee, WI) was converted to the p-carbobenzyloxy derivative (2) by the addition of 1.2 equivalents benzyl chloroformate in saturated aqueous sodium bicarbonate (NaHCO3) for 20 minutes at 23° C. That derivative was treated with 1.1 equivalents phosphorous pentachloride (PCl5) in chloroform at 50° C. for 2 hours. Pyridine (5 equivalents) and p-nitrophenol (3 equivalents) were added at 23° C. and subsequent workup provided the ethyl p-nitrophenyl phosphonate (3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04659567 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-557e42d8b708457abe6792d4987dd115 |
| 出典メモ | uspto-grants-1987_04 |