Ciprofloxacin → HCID 70432235, compound

Participants

Reaction Steps

A mixture of 1.2 g of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline -3-carboxylic acid, 1.13 g of ethyl iodide, 0.73 g of triethylamine and 20 ml of N,N-dimethylformamide is heated at 70°-80° C. for 2.5 h. The solvent is removed by distillation in vacuo, and the residue is suspended in water. The product is filtered off with suction, washed with H2O and pressed on a clay plate. 1.15 g of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-1-piperazinyl)-quinoline-3-carboxylic acid hydroiodide of decomposition point 306° C. are obtained.

Provenance & Evidence