HCID 13769976, compound → HCID 13769978, compound

Participants

Reaction Steps

3-(3-Nitropyridin-2-yl)aminothiophene-2-carboxylic acid methylester (14.6 g) is added to a suspension of dihydrate tin chloride (64 g) in conc. HCl (210 ml) and ethanol (235 ml). The reaction mixture is refluxed for 2 hours obtaining the gradual dissolution of the reagents and subsequent precipitation of a solid. After cooling at the room temperature, the solid is filtered and triturated with a saturated solution of NaHCO3, filtered, washed with H2O and dried to give 6.4 g (56%) of the title product, melting at 273°-279° C.

Provenance & Evidence