Hydrochloric Acid → 7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Participants

Reaction Steps

A suspension of 8-methoxy-2-oxo-1H-3-benzazepine (20.4 g, 0.105 m) in tetrahydrofuran (500 ml) was added to 1M borane in tetrahydrofuran (300 ml) stirred at 5° . The mixture was heated to reflux for 2 hours, cooled, treated with 3N hydrochloric acid (300 ml), concentrated in vacuo to remove tetrahydrofuran and heated to reflux for 1 hour. The mixture was concentrated in vacuo, filtered and the filter cake was dissolved in methanol, heated to reflux, dried with magnesium sulfate and concentrated in vacuo to afford 7-methoxy-2,3,4,5-tetrahydro-1H-3benzazepine hydrochloride, m.p. 229°-231°.

Provenance & Evidence