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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 542728Generated: October 31, 2026

Hydrochloric Acid → 8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

https://huagongshe.com/reaction/542728

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant3-Acetyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 13853355—
Product8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochlorideHCID 21242875—

Reaction Steps

Alternatively, 3-acetyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine is treated with 3N hydrochloric acid to give 8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride. Refluxing this compound with 48% hydrobromic acid gives 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04659706
Source datasetuspto-grants-1987_04
ORD IDord-3c03af3eaead489b94acb301cdb0560e
Source noteuspto-grants-1987_04