反应详情

A solution of 3-acetyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine (2.3 g, 0.01 m) in acetic acid (20 ml) is treated with a solution of bromine (1.8 g, 0.011 m) in acetic acid (10 ml). The mixture is warmed to 70° for 1.5 hours, concentrated in vacuo and partitioned between water and ethyl acetate. The ethyl acetate phase is washed, dried with sodium sulfate and concentrated in vacuo to give 3-acetyl-8-bromo-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine.

1. temperatureThe mixture is warmed to 70° for 1.5 hours
2. concentrationconcentrated in vacuo
3. custompartitioned between water and ethyl acetate
4. washThe ethyl acetate phase is washed
5. dry with materialdried with sodium sulfate
6. concentrationconcentrated in vacuo