HCID 21242880, compound → HCID 21242923, compound

HRID 542734Notes

Reaction equation

HRID 542734 reaction equation
[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12](Br)[C:13]([O:19][CH3:20])=[C:14]([S:15]([CH3:18])(=[O:17])=[O:16])[C:7]=2[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[CH:12][C:13]([O:19][CH3:20])=[C:14]([S:15]([CH3:18])(=[O:16])=[O:17])[C:7]=2[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 21242880HCID 21242880, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21242923HCID 21242923, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 3-acetyl-8-bromo-7-methoxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (3.7 g, 0.01 m) and 10% palladium-on-carbon (0.37 g) in methanol (50 ml) is stirred in an atmosphere of hydrogen (60 psi) until uptake is complete. The mixture is degassed, filtered and concentrated in vacuo to give 3-acetyl-7-methoxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. customThe mixture is degassed
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2e9db79b2aa84ba5ab7b670a5f742ba9
Source dataset
uspto-grants-1987_04
Patent number
US04659706

Reaction notes

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