反应详情

A mixture of 5-bromo-3-hydroxytoluene (93 g, 0.5 m) and sodium hydroxide (21 g, 0.5 m) in water (200 ml) is stirred at 10°, treated with dimethyl sulfate (63 g, 0.5 m) over 1 hour, refluxed for 2 hours and cooled. The mixture is diluted with water and extracted with ether. The ether extract is washed, dried with sodium sulfate and concentrated in vacuo to give 5-bromo-3-methoxytoluene.

1. temperaturerefluxed for 2 hours
2. temperaturecooled
3. extractionextracted with ether
4. extractionThe ether extract
5. washis washed
6. dry with materialdried with sodium sulfate
7. concentrationconcentrated in vacuo