反应详情

A mixture of 5-bromo-3-methoxyphenylacetonitrile (22.6 g, 0.1 m) and 10% aqueous sodium hydroxide (300 ml) in ethanol (225 ml) is heated to 95° for 18 hours. The mixture is concentrated in vacuo, acidified with 10% hydrochloric acid and extracted with ethyl acetate. The ethyl acetate extract is washed, dried with sodium sulfate and concentrated in vacuo to give 5-bromo-3-methoxyphenylacetic acid.

1. temperatureis heated to 95° for 18 hours
2. concentrationThe mixture is concentrated in vacuo
3. extractionextracted with ethyl acetate
4. extractionThe ethyl acetate extract
5. washis washed
6. dry with materialdried with sodium sulfate
7. concentrationconcentrated in vacuo