HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl bromide → 8-acetoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl bromide | HCID 10482 | — |
| Reactant | 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide | HCID 21242877 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 8-acetoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide | HCID 21242936 | — |
Reaction Steps
A mixture of 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (3.2 g, 0.01 m) in trifluoroacetic acid (25 ml) is stirred at 25° and treated with acetyl bromide (1.4 g, 0.011 m). The mixture is stirred at 25° and concentrated in vacuo to give 8-acetoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04659706 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-d3d7e37e2a2345a3908af1f87780aa25 |
| Source note | uspto-grants-1987_04 |