Sodium Hydroxide → HCID 13920598, compound

HRID 542758Notes

Reaction equation

HRID 542758 reaction equation
[OH-:1].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[C:17](=[C:18]3[CH2:23][CH2:22][N:21](OCC)[C:20](=[C:27]=[O:28])[CH2:19]3)[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[CH2:10][CH2:9][C:8]=2[CH:29]=1>C(O)C>[C:27]([OH:28])(=[O:1])[CH3:20].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[C:17](=[C:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[CH2:10][CH2:9][C:8]=2[CH:29]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86741426HCID 86741426, compound

Product 1

HCID 13920598HCID 13920598, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To 12 grams of sodium hydroxide in 30 mL ethyl alcohol (70%) add 6 grams of 8-chloro-6,11-dihydro-11-(1-ethoxy-carbonyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (prepared as described in U.S. Pat. No. 4,282,233) and reflux with stirring for 24 hours. After about the first 6-8 hours an additional 30 mL of 70% ethyl alcohol may be added.

Workup

  1. customprepared
  2. temperature4,282,233) and reflux

Sources & evidence

ORD record
ord-9dbfe43cba3b4772b14126291dfb4fbb
Source dataset
uspto-grants-1987_04
Patent number
US04659716

Reaction notes

Loading…