Benzo(B)Thiophene → Benzo(b)thiophene, 3-bromo-

Participants

Reaction Steps

To a solution of 25 g of 1-benzothiophene in 100 ml of carbon tetrachloride at 15° C. were added 29.5 g of bromine over 6 hours. The reaction was allowed to stir at room temperature for 48 hours, at which time the reaction mixture was washed twice with a 1N aqueous sodium thiosulfate solution. The organic solution was dried over magnesium sulfate and evaporated to dryness. The resulting oil was vacuum distilled at 2 torr. Fractions collected between about 86°-90° L C. provided 27.7 g of the desired subtitle intermediate.

Provenance & Evidence