反应详情

A mixture of 2.2 g of 2-methylbenzo[b]thiophene-3-carboxaldehyde, 4.9 g of ethyl 3-aminocrotonate, and 10 ml of ethanol were heated to reflux for approximately 18 hours. An additional 1.6 g of ethyl 3-aminocrotonate were added and the reaction was heated an additional 24 hours at reflux. The reaction mixture was cooled and concentrated and the resulting solid was recovered by filtration providing 2.15 g of the desired title product, m.p. 191°-193° C.

1. temperaturewere heated
2. temperatureto reflux for approximately 18 hours
3. temperaturethe reaction was heated an additional 24 hours
4. temperatureat reflux
5. temperatureThe reaction mixture was cooled
6. concentrationconcentrated
7. filtrationthe resulting solid was recovered by filtration