HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 13826855, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | 5-Bromo-3-(dibromomethyl)-1-benzothiophene | HCID 20207236 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 13826855 | HCID 13826855 | 28.2% |
Reaction Steps
A mixture of 2.35 g of 5-bromo-3-(dibromomethyl)benzo[b]thiophene and 1.6 g of ethyl 3-aminocrotonate in 4 ml of ethanol was heated to reflux for 14 hours. The mixture was evaporated in vacuo and the residue was purified by chromatography over silica gel to provide 0.8 g of the desired title product, m.p. 68°-70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04659717 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-4ea5379d476648cf9fe3e8e432ad3933 |
| Source note | uspto-grants-1987_04 |