2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 13826860, compound

HRID 542778Notes

Reaction equation

HRID 542778 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:11]([CH:12]=O)=[CH:10][S:9][C:8]=2[CH:14]=1)([O-:3])=[O:2].[NH2:15]/[C:16](/[CH3:23])=[CH:17]\[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[CH3:23][C:16]1[NH:15][C:16]([CH3:23])=[C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:12]([C:11]2[C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:14][C:8]=3[S:9][CH:10]=2)[C:17]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

3

Reactant 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 13826894HCID 13826894, compound

Product 1

HCID 13826860HCID 13826860, compoundYield 38.5%

Procedure

Following the procedure of Example 16C, 0.5 g of 6-nitrobenzo[b]thiophene-3-carboxaldehyde and 0.7 g of ethyl 3-aminocrotonate were reacted to provide 0.4 g of the desired title product, m.p. 191°-194° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6b729e71b76c4854b7e8e51a81be3030
Source dataset
uspto-grants-1987_04
Patent number
US04659717

Reaction notes

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