HRID542780

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21601

1H-Isoindole-1,3(2H)-dione, 2-(2-oxiranylmethyl)-

C11H9NO3

HCID7164645

[3-(Piperidinomethyl)phenyl]methanol

C13H19NO

PRODUCTS

生成物

结构：O=C1c2ccccc2C(=O)N1CC(O)COCc1cccc(CN2CCCCC2)c1

HCID13535476

未命名化合物

收率 42.1%

CONDITIONS

反应条件

温度: 130 °C

PROCEDURE

实验过程

A mixture of 10.25 g (0.05 mol) of 3-(1-piperidylmethyl)-benzyl alcohol and 10.15 g (0.05 mol) of N-(2,3-epoxypropyl)-phthalimide is stirred under nitrogen for 80 minutes at 130° C. The viscous resin obtained is chromatographed on silica gel, using methylene chloride/methanol 9:1. The main fraction yields 8.60 g (42%) of the title compound in the form of a light brown oil after concentration by evaporation.

WORKUP

后处理

customThe viscous resin obtained
customis chromatographed on silica gel