Methanol → 7-methoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

HRID 542805노트

반응식

HRID 542805 반응식
[CH3:1][O-:2].[Na+].F[C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:22])[C:10]([C:16]3[N:20]([CH3:21])[N:19]=[N:18][N:17]=3)=[CH:11][N:12]2[CH3:15])=[CH:7][CH:6]=1.CO>O>[CH3:1][O:2][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:22])[C:10]([C:16]3[N:20]([CH3:21])[N:19]=[N:18][N:17]=3)=[CH:11][N:12]2[CH3:15])=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 134744537-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

생성물 1

HCID 134744117-methoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of sodium methoxide (0.47 g), 7-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (2.0 g) and methanol (40 ml) was boiled under reflux for 43 hours. The mixture was cooled and poured into water (100 ml). The solid was collected by filtration, washed with boiling industrial methylated spirit (50 ml) and dried to give the novel compound 7-methoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone, m.p. 270°-273°.

후처리

  1. temperatureunder reflux for 43 hours
  2. temperatureThe mixture was cooled
  3. filtrationThe solid was collected by filtration
  4. washwashed with boiling industrial methylated spirit (50 ml)
  5. customdried

출처 및 근거

ORD 기록
ord-7078bb8b64b246a1a9b602dc6cd82545
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659718

반응 노트

불러오는 중…