反应详情

A mixture of sodium methoxide (0.47 g), 7-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (2.0 g) and methanol (40 ml) was boiled under reflux for 43 hours. The mixture was cooled and poured into water (100 ml). The solid was collected by filtration, washed with boiling industrial methylated spirit (50 ml) and dried to give the novel compound 7-methoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone, m.p. 270°-273°.

1. temperatureunder reflux for 43 hours
2. temperatureThe mixture was cooled
3. filtrationThe solid was collected by filtration
4. washwashed with boiling industrial methylated spirit (50 ml)
5. customdried