2-Bromopropane → HCID 20207250, compound

Participants

Reaction Steps

A mixture of 1-methyl-3-(1H-tetrazol-5-yl)-4-quinolone (0.74 g), isopropyl bromide (0.31 ml), anhydrous potassium carbonate (0.45 g) and butanone (30 ml) was boiled under reflux for 16 hours. More isopropyl bromide (0.5 ml) was added and boiling under reflux was continued for 7 hours. More isopropyl bromide (0.5 ml) was added and boiling under reflux was continued for a further 24 hours. The mixture was evaporated to dryness and the residue treated with water (30 ml). The solid product was collected by filtration and partially purified by high pressure liquid chromatography over silica gel using dichloromethane:methanol 95:5 as the eluent. The solid product was recrystallised from ethyl acetate:diethyl ether 3:2 to give the novel compound 3-(2-isopropyl-1H-tetrazol-5-yl)-1-methyl-4-quinolone, m.p. 134°-137°.

Provenance & Evidence