Morpholine → HCID 13474433, compound

HRID 542824Notes

Reaction equation

HRID 542824 reaction equation
F[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[N:17]([CH3:18])[N:16]=[N:15][N:14]=3)=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH3:12][N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:11]=2)[C:6](=[O:19])[C:7]([C:13]2[N:17]([CH3:18])[N:16]=[N:15][N:14]=2)=[CH:8]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 134744537-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

Product 1

HCID 13474433HCID 13474433, compound

Procedure

In a similar way to that described in Example 30, 7-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (1 g) was heated with morpholine (25 ml) at 100° for 103 hours to give 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-morpholino-4-quinolone, m.p. 235°-238°.

Sources & evidence

ORD record
ord-1abc2ab36fb448b68f5cec4eb710e603
Source dataset
uspto-grants-1987_04
Patent number
US04659718

Reaction notes

Loading…