Formic Acid → HCID 13474454, compound

HRID 542825Notes

Reaction equation

HRID 542825 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:17])[CH2:10][C:11]1[N:15]([CH3:16])[N:14]=[N:13][N:12]=1.[CH:18](O)=O>C(OCC)C>[CH3:1][N:2]1[C:3]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:9](=[O:17])[C:10]([C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:18]1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 13474395HCID 13474395, compound

Product 1

HCID 13474454HCID 13474454, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1-(2-methylaminophenyl)-2-(1-methyl-1H-tetrazol-5-yl)ethanone (0.2 g) and formic acid (5 ml) was heated on a steam bath for 16 hours. The mixture was cooled to ambient temperature and diluted with diethyl ether (80 ml). The resulting precipitate was collected and crystallised from industrial methylated spirit to give the novel compound 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone, m.p. 219°-221°, identical to the product of Example 1(a).

Workup

  1. temperaturewas heated on a steam bath for 16 hours
  2. customThe resulting precipitate was collected
  3. customcrystallised from industrial methylated spirit

Sources & evidence

ORD record
ord-4259a533c02340a18f762943386f5a72
Source dataset
uspto-grants-1987_04
Patent number
US04659718

Reaction notes

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