Isopropanol → HCID 13077563, compound

Participants

Reaction Steps

A solution of 5.5 g (0.009 mole) of 6-methoxy-4-methyl-N-[6-(1-piperazinyl)hexyl]-8-quinolinamine, trihydrobromide, compd. with 2-propanol (1:0.3), hemihydrate in 100 ml of water was made basic with concentrated ammonium hydroxide and extracted with dichloromethane. The extract was washed, dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness under vacuum. A solution of the concentrate and 1.8 g (0.012 mole) of cyanodithioimidocarbonic acid, dimethyl ester in 100 ml of toluene was stirred at room temperature for 64 hours, then washed with water, dried, and concentrated to dryness. Recrystallization from 2-propanol afforded 2.7 g (66%) of the title compound as yellow needles, mp 97°-99°.

Provenance & Evidence