反应详情

One hundred grams of 1,2,3,4-tetrahydro-1-naphthol were dissolved in 1 liter of chloroform and 53.9 ml of pyridine. The mixture was cooled with an external ice bath and 98.6 ml of thionyl chloride were added over a 1 hour period. The reaction mixture was stirred an additional 2 hours with cooling, concentrated in vacuo, and the residue taken up in 1 liter of methylene chloride. The methylene chloride solution was washed with water, a 5% sodium bicarbonate solution, water again, dried over sodium sulfate, and evaporated to dryness to provide the desired intermediate 1,2,3,4-tetrahydro-1-chloronaphthalene.

1. temperatureThe mixture was cooled with an external ice bath
2. temperaturewith cooling
3. concentrationconcentrated in vacuo
4. washThe methylene chloride solution was washed with water
5. dry with materiala 5% sodium bicarbonate solution, water again, dried over sodium sulfate
6. customevaporated to dryness