HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane → 1-allyl-1H-pyrrole-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | 1-Isopropyl-1H-pyrrole-2-carbaldehyde | HCID 3155970 | — |
| Reactant | 1-Allyl-1H-pyrrole-2-carbaldehyde | HCID 10942480 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-allyl-1H-pyrrole-2-carbonitrile | HCID 13589311 | 50% |
Reaction Steps
In the same manner as described in Reference Example 2 (1) except that 1-allylpyrrole-2-carbaldehyde (prepared in the same manner as described in Can. J. Chem., 55, 4112, 1977, b.p. 80°-83° C./7 mmHg) (8.1 g, 60 mmole) is used instead of 1-isopropylpyrrole-2-carbaldehyde and further the product is isolated by silica gel column chromatography (solvent, cyclohexane:dichloromethane=3:1) instead of distillation under reduced pressure, there is obtained 1-allylpyrrole-2-carbonitrile (4.0 g, yield: 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04659726 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-b4583f28c3ea49f6abb5e5a3e38595c8 |
| Source note | uspto-grants-1987_04 |