反应详情

A mixture of 2-ethoxy-1-ethoxycarbonyl-1-nitroethene (5.7 g) and 2-amino-5-bromopyridine (5.2 g) in toluene was heated at reflux with slow removal of the ethanol formed during 2 hours. The reaction mixture was cooled and concentrated in vacuo to give a yellow powder which was triturated with hot ethanol, to give 2-(5-bromopyrid-2-ylamino)-1-ethoxycarbonyl-1-nitroethene (6.0 g) in the form of a pale yellow powder, m.p. 141°-142° C.

1. temperaturewas heated
2. customformed during 2 hours
3. temperatureThe reaction mixture was cooled
4. concentrationconcentrated in vacuo
5. customto give a yellow powder which
6. customwas triturated with hot ethanol