Adenine → HCID 20207437, compound

Participants

Reaction Steps

A mixture of 6-aminopurine (13.5 g), triethylamine (10.1 g) and 2-ethoxy-1,1-bis(ethoxycarbonyl)ethene (21.6 g) in dimethylformamide (100 ml) was heated at reflux for 16 hours. It was then cooled and the product which separated was crystallised from dimethylformamide and washed with diethyl ether, to give 2-(purin-6-ylamino)-1,1-bis(ethoxycarbonyl)ethene (23 g), in the form of colourless, fluffy crystals, m.p. 234° C. (with decomposition).

Provenance & Evidence