反应详情

A stirred mixture of 2,6-diaminopyridine (0.3 g) and 2-ethoxy-1,1-bis(phenylsulphonyl)ethene (2.1 g) in toluene (50 ml) was heated at reflux for 2 hours. The mixture was cooled, and concentrated in vacuo, and the resulting solid was subjected to medium pressure chromatography on silica gel, eluting with acetone, to give 2,6-bis[2,2-bis(phenylsulphonyl)ethen-1-ylamino]pyridine (0.45 g), in the form of a white powder, m.p. 299°-300° C.

1. temperaturewas heated
2. temperatureat reflux for 2 hours
3. temperatureThe mixture was cooled
4. concentrationconcentrated in vacuo
5. washeluting with acetone