P-Anisidine → HCID 70427210, compound

HRID 542894Notes

Reaction equation

HRID 542894 reaction equation
[C:1]1([S:7]([C:10]#[C:11][CH3:12])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>CO>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:11]([CH3:12])=[CH:10][S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 137626Phenyl prop-1-ynyl sulphone

Product 1

HCID 70427210HCID 70427210, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stirred solution of 1-phenylsulphonylpropyne (0.25 g) in anhydrous methanol (10 ml) was treated with 4-anisidine (0.17 g) and the homogeneous mixture was allowed to stand at room temperature overnight. The methanol was removed in vacuo to give 1-(4-methoxyphenylamino)-1-methyl-2-(phenylsulphonyl)ethene (0.4 g) in the form of a dark brown oil [NMR (in deuterated dimethylsulphoxide: 2.16, 3.76, 7.04, 7.62, 7.84, 8.68 ppm].

Workup

  1. customThe methanol was removed in vacuo

Sources & evidence

ORD record
ord-1f01ed5c36a845f69aa8ab126e92a626
Source dataset
uspto-grants-1987_04
Patent number
US04659727

Reaction notes

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