Diethyl (ethoxymethylene)malonate → HCID 10449422, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-amino-2,3-dimethyl-3H-imidazo-[4,5-b]pyridine (4.86 g) and 2-ethoxy-1,1-bis-(ethoxycarbonyl)ethene (7.13 g) in toluene (200 ml) was stirred and heated at reflux for 2 hours and then it was evaporated to dryness. The residue was extracted 3 times with boiling petroleum ether (b.p. 80°-100° C.), the extracts were filtered while hot and the filtrate was then cooled to 0° C. The resulting yellow solid was filtered off, to give 1,1-bis(ethoxycarbonyl)-2-(2,3-dimethyl-3H-imidazo-[4,5-b]pyrid-5-ylamino)ethene (8.4 g) in the form of a yellow sold, m.p. 128°-130° C.

Provenance & Evidence