N-Methylbutylamine → HCID 70447683, compound

HRID 543010Notes

Reaction equation

C([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:20]([CH2:21][CH2:22][C@:6]12[CH3:7])[C:19]1[CH:18]=[CH:17][C:16]([OH:23])=[CH:15][C:14]=1[CH:13]=[C:12]3[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][C:34]([OH:36])=O)(=O)C.[CH3:37][NH:38][CH2:39][CH2:40][CH2:41][CH3:42]>>[CH2:39]([N:38]([CH3:37])[C:34](=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][C:12]1[C@@H:11]2[C@@H:20]([C:19]3[CH:18]=[CH:17][C:16]([OH:23])=[CH:15][C:14]=3[CH:13]=1)[CH2:21][CH2:22][C@@:6]1([CH3:7])[C@H:8]2[CH2:9][CH2:10][C@@H:5]1[OH:4])[CH2:40][CH2:41][CH3:42]

Participants

Reactant 2

HCID 8068N-Methylbutylamine

HCID 70447827HCID 70447827, compound

Product 1

HCID 70447683HCID 70447683, compound

Procedure

The process described in the first two paragraphs of Example 1 was repeated except that 11-(17β-acetoxy-3-hydroxyoestra-1,3,5(10),6-tetraen-7-yl)undecanoic acid and N-methyl-N-butylamine were used as starting materials. There was thus obtained as an oil N-n-butyl-N-methyl-11-(3,17β-dihydroxyoestra-1,3,5(10),6-tetraen-7-yl)undecanamide, the structure of which was confirmed by proton magnetic resonance and mass spectroscopy.

Sources & evidence

ORD record: ord-e9ad62c88f7a41798c2b7a84a7ae4359
Source dataset: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04659516

Reaction notes

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