Magnesium monoxide → 1404-26-8

HRID 543055Notes

Reaction equation

HRID 543055 reaction equation
[CH3:1][CH2:2][CH:3]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([NH:11][C@H:12]([C:16]([NH:18][C@H:19]([C:23]([NH:25][C@H:26]([C:30]([NH:32][C@@H:33]1[C:61](=[O:62])[NH:60][C@H:59]([CH2:63][CH2:64][NH2:65])[C:57](=[O:58])[NH:56][C@H:55]([CH2:66][C:67]2[CH:68]=[CH:69][CH:70]=[CH:71][CH:72]=2)[C:53](=[O:54])[NH:52][C@@H:51]([CH2:73][CH:74]([CH3:76])[CH3:75])[C:49](=[O:50])[NH:48][C@@H:47]([CH2:77][CH2:78][NH2:79])[C:45](=[O:46])[NH:44][C@@H:43]([CH2:80][CH2:81][NH2:82])[C:41](=[O:42])[NH:40][C@@H:39]([C@H:83]([OH:85])[CH3:84])[C:37](=[O:38])[NH:36][CH2:35][CH2:34]1)=[O:31])[CH2:27][CH2:28][NH2:29])=[O:24])[C@H:20]([OH:22])[CH3:21])=[O:17])[CH2:13][CH2:14][NH2:15])=[O:10])[CH3:4].OS(O)(=O)=O.[O-2].[Mg+2]>O>[CH3:1][CH2:2][CH:3]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([NH:11][C@H:12]([C:16]([NH:18][C@H:19]([C:23]([NH:25][C@H:26]([C:30]([NH:32][C@@H:33]1[C:61](=[O:62])[NH:60][C@H:59]([CH2:63][CH2:64][NH2:65])[C:57](=[O:58])[NH:56][C@H:55]([CH2:66][C:67]2[CH:68]=[CH:69][CH:70]=[CH:71][CH:72]=2)[C:53](=[O:54])[NH:52][C@@H:51]([CH2:73][CH:74]([CH3:76])[CH3:75])[C:49](=[O:50])[NH:48][C@@H:47]([CH2:77][CH2:78][NH2:79])[C:45](=[O:46])[NH:44][C@@H:43]([CH2:80][CH2:81][NH2:82])[C:41](=[O:42])[NH:40][C@@H:39]([C@H:83]([OH:85])[CH3:84])[C:37](=[O:38])[NH:36][CH2:35][CH2:34]1)=[O:31])[CH2:27][CH2:28][NH2:29])=[O:24])[C@H:20]([OH:22])[CH3:21])=[O:17])[CH2:13][CH2:14][NH2:15])=[O:10])[CH3:4]

Participants

4

Reactant 2

HCID 6850729Magnesium monoxideHCID 49800003HCID 49800003, compound

Product 1

HCID 498000041404-26-8

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.8 g of Polymyxin B sulfate (purchased from Sigma Chemicl Co.; 8000 units/mg) were dissolved in 600 ml water and 25 g of Fiber A were added therein, followed by 5 hours shaking. Then 1.5 g of magnesium oxide were added thereto, followed by 12 hours shaking at room temperature. Thereafter, the fiber was taken out from the mother liquor, packed in a column and washed with 4800 ml of 0.1 N-hydrochloric acid. Polymyxin B-fixed fiber (Fiber D) was obtained. The amount of fixed Polymyxin on Fiber D was determined by the same method of Example 1. It was 39 mg/g.

Workup

  1. addition25 g of Fiber A were added
  2. waitfollowed by 12 hours
  3. stirringshaking at room temperature
  4. washwashed with 4800 ml of 0.1 N-hydrochloric acid

Sources & evidence

ORD record
ord-738f01eca5334f429ef56a67c5e06e6c
Source dataset
uspto-grants-1987_04
Patent number
US04661260

Reaction notes

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