Water → HCID 178477257, compound

HRID 543110Notes

Reaction equation

HRID 543110 reaction equation
[P:1]([O-:8])([O:5]CC)[O:2]CC.O.[NH2:10][C:11]1[NH:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1>C(O)C>[CH2:13]([P:1](=[O:2])([O-:5])[O-:8])[CH3:14].[N:12]1[C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[NH:15][C:11]=1[NH3+:10].[N:12]1[C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[NH:15][C:11]=1[NH3+:10]

Participants

5

Reactant 3

HCID 962WaterHCID 136242-AminobenzimidazoleHCID 3780918Diethylphosphite

Product 1

HCID 178477257HCID 178477257, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 27.62 g. (0.02 moles) of diethyl phosphite and 20 ml. of water 13.31 g. (0.1 moles) of 2-amino-benzimidazole and 150 ml. of ethanol are added. The reaction mixture is refluxed for 5 hours. The solvent and the excess of diethyl phosphite are evaporated in vacuo. The crystalline substance obtained is dried over phosphorus pentoxide. Yield of the title compound is 95%.

Workup

  1. additionTo a mixture of 27.62 g
  2. temperatureThe reaction mixture is refluxed for 5 hours
  3. customThe solvent and the excess of diethyl phosphite are evaporated in vacuo
  4. customThe crystalline substance obtained
  5. dry with materialis dried over phosphorus pentoxide

Sources & evidence

ORD record
ord-d968154cfaa04232919562a526cbc7ad
Source dataset
uspto-grants-1987_04
Patent number
US04661477

Reaction notes

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