HuagongsheHuagongshe Chemistry Print Report · For research reference only
Norpyridostigmine → 3-(Dimethylcarbamoyloxy)-1-(cyclopropylcarbonyloxymethyl)pyridinium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Norpyridostigmine | HCID 98821 | — |
| Reactant | Chloromethyl cyclopropanecarboxylate | HCID 19069329 | — |
| Product | 3-(Dimethylcarbamoyloxy)-1-(cyclopropylcarbonyloxymethyl)pyridinium chloride | HCID 20205838 | 92.2% |
Reaction Steps
3-Dimethylcarbamoyloxypyridine (1.66 g) and chloromethylcyclopropanecarboxylate (2.70 g) were heated to 90° C. with stirring for 3 hrs. The reaction mixture was treated in a similar manner as described in Example 1 to give 2.77 g of 3-(dimethylcarbamoyloxy)-1-(cyclopropylcarbonyloxymethyl)pyridinium chloride as oil. The structure was determined by N.M.R.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04661502 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-aa35de5c9b1d480d95953ad73d6d28b4 |
| Source note | uspto-grants-1987_04 |