Norpyridostigmine → 3-(Dimethylcarbamoyloxy)-1-(hexanoyloxymethyl)-pyridinium chloride

HRID 543158노트

반응식

HRID 543158 반응식
[CH3:1][N:2]([CH3:12])[C:3]([O:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[Cl:13][CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>>[Cl-:13].[CH3:1][N:2]([CH3:12])[C:3]([O:5][C:6]1[CH:7]=[N+:8]([CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:9]=[CH:10][CH:11]=1)=[O:4]

참가 물질

3

반응물 2

HCID 98821NorpyridostigmineHCID 525229Chloromethyl hexanoate

생성물 1

HCID 202058363-(Dimethylcarbamoyloxy)-1-(hexanoyloxymethyl)-pyridinium chloride수율 80.2%

실험 절차

3-Dimethylcarbamoyloxypyridine (1.66 g) and chloromethylhexanoate (2.0 g) were heated to 90° C. with stirring for 3 hours. The reaction mixture was treated in a similar manner as described in Example 1 to give 2.65 g of 3-(dimethylcarbamoyloxy)-1-(hexanoyloxymethyl)-pyridinium chloride as colorless powdery crystals. It was impossible to precisely measure the melting point because of high hygroscopicity. The structure was determined by N.M.R.

후처리

  1. additionThe reaction mixture was treated in a similar manner

출처 및 근거

ORD 기록
ord-390da6494e7b419eac2dc5ef8c661421
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661502

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